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[Relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia responding to retreatment with

Hiroshi Hashimoto¹, Yuhei Tamura¹, Kaori Yamada¹

¹Department of Hematology, Kindai Nara Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology

|September 6, 2023

Abstract:

A 72-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) was treated with dasatinib (week1: 50 mg/day, week2: 70 mg/day, week3-: 100 mg/day) and prednisolone from June 2017. However, in January 2018, it relapsed with the T315I mutation. Although the treatment was changed to ponatinib 30 mg/day, he experienced a second relapse in June 2018. Following confirmation of CD22 positivity, he was treated with three cycles of inotuzumab ozogamicin (InO), resulting in CR. He was CR for 2.9 years before relapsing for the third time in May 2021. Because the patient was still CD22-positive, InO was given again, and the patient achieved CR at the end of the second cycle. We had a case where re-administering InO was effective as a salvage therapy for relapsed/refractory Ph+ALL (r/r Ph+ALL) in an elderly patient.

Keywords:

Inotuzumab ozogamicin Philadelphia chromosome-positive acute lymphoblastic leukemia T315I mutation

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