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The emerging Janus face of SVEP1 in development and disease

Jared S Elenbaas1, In-Hyuk Jung2, Ariella Coler-Reilly3

  • 1Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Medical Scientist Training Program, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Trends in Molecular Medicine
|September 6, 2023
PubMed

Insights

Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a circulating protein linked to numerous chronic diseases. Further research is needed to understand its role in vascular health and disease mechanisms.

Area of Science:

  • Biochemistry
  • Genetics
  • Cardiovascular Science

Background:

  • Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein found in circulation.
  • Recent studies link SVEP1 to various human traits and chronic diseases, including cardiac conditions, diabetes, and dementia.

Purpose of the Study:

  • To review the known associations of SVEP1 with human traits and diseases.
  • To highlight the critical role of SVEP1 in vascular development and disease as shown in animal models.
  • To identify knowledge gaps regarding SVEP1's molecular and cellular mechanisms.

Main Methods:

  • Literature review of plasma proteomic and genomic studies.
  • Analysis of findings from animal models of SVEP1 function.
  • Synthesis of current understanding of SVEP1's role in health and disease.

Main Results:

  • SVEP1 is associated with multiple chronic diseases, including cardiac death and disease, diabetes, glaucoma, dementia, and aging.
  • Evidence suggests causal links between SVEP1 and several of these conditions.
  • Animal studies confirm SVEP1's importance in vascular development and disease pathogenesis.

Conclusions:

  • SVEP1 is a significant protein with widespread implications for human health, particularly in chronic and vascular diseases.
  • The molecular and cellular mechanisms underlying SVEP1's functions are not well-defined.
  • Further investigation is warranted to explore SVEP1's diagnostic, prognostic, and therapeutic potential.

Keywords:
SVEP1agingchronic diseasedevelopmentextracellular matrixvascular disease

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