Related Experiment Video
Updated: Jul 17, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
What changed after the 2022 guidelines for pulmonary hypertension?
Mona Lichtblau1, Anna Titz2, Barbara Bahrampoori2
1Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.
Pulmonary hypertension (PH), affecting 1% globally, requires updated management. This review covers new European Society of Cardiology (ESC) /European Respiratory Society (ERS) guidelines for PH diagnosis and treatment in clinical practice.
Area of Science:
- Cardiology
- Respiratory Medicine
- Clinical Practice Guidelines
Background:
- Pulmonary hypertension (PH) affects approximately 1% of the global population, representing a significant health burden.
- Existing diagnostic and treatment protocols for PH are subject to periodic updates to reflect advancements in medical understanding and technology.
Purpose of the Study:
- To provide a comprehensive overview of the recent revisions in the European Society of Cardiology (ESC) /European Respiratory Society (ERS) guidelines for pulmonary hypertension (PH).
- To analyze the implications of these updated guidelines for the daily clinical management of patients with PH.
Main Methods:
- This study is a review article.
- It synthesizes information from the latest ESC/ERS guidelines on PH diagnosis and treatment.
- The review focuses on practical applications for clinicians.
Main Results:
- The revised ESC/ERS guidelines introduce novelties in the diagnostic algorithms for PH.
- Updated treatment strategies are presented, potentially altering patient management pathways.
- The guidelines emphasize a multidisciplinary approach to PH care.
Conclusions:
- The updated ESC/ERS guidelines offer significant advancements in the diagnosis and treatment of pulmonary hypertension.
- These revisions are expected to enhance clinical decision-making and improve patient outcomes in everyday practice.
- Adoption of these novelties is crucial for healthcare professionals managing PH patients.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...

