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[Pharmacokinetic study of mitoxantrone]
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 1, 1986
Summary
Mitoxantrone pharmacokinetics were studied in cancer patients. This anthraquinone antitumor agent showed rapid blood clearance and distribution, fitting a three-compartment model in Japanese and European populations.
Area of Science:
- Pharmacology
- Oncology
- Pharmacokinetics
Context:
- Mitoxantrone is an anthraquinone antitumor agent.
- Investigated pharmacokinetics in breast cancer and malignant lymphoma patients.
- Cooperative study across 5 institutions.
Purpose:
- To investigate the pharmacokinetics of mitoxantrone.
- To determine drug behavior in Japanese patients.
- To compare single and repeated administration schedules.
Summary:
- Single dose (10 mg/m2) IV infusion showed rapid clearance (total body clearance 326.8 ml/m2) and distribution (steady-state volume 1,112 l/m2).
- Half-lives were 0.16 h (alpha), 1.58 h (beta), and 83.4 h (gamma).
- Repeated administration revealed similar pharmacokinetics in patients without third space, but reduced clearance in those with third space. Japanese patient data aligned with European data, fitting a three-compartment model.
Impact:
- Provides crucial pharmacokinetic data for mitoxantrone in cancer treatment.
- Highlights the influence of 'third space' on drug clearance.
- Confirms similar mitoxantrone pharmacokinetics across different ethnic groups, supporting broader clinical application.