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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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First report of Candida auris in Romania: clinical and molecular aspects

Adriana Mihaela Stanciu1,2, Dragoș Florea3,4, Marius Surleac2

  • 1"Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu Street no 37, Bucharest, 050474, Romania.

Antimicrobial Resistance and Infection Control
|September 6, 2023
PubMed

Insights

Candida auris, a dangerous fungus, is appearing in Romania. This report details early cases, highlighting its resistance to antifungals and identification challenges.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Candida auris is an emerging opportunistic fungal pathogen causing global health concerns.
  • High mortality rates, antifungal resistance, and diagnostic difficulties characterize C. auris.
  • Outbreaks of C. auris necessitate detailed clinical and epidemiological surveillance.

Purpose of the Study:

  • To report the initial cases of Candida auris in Romania.
  • To provide clinical and epidemiological data for these cases.
  • To analyze whole genome sequencing data of the identified strains.

Main Methods:

  • Case identification in three Bucharest hospitals.
  • Clinical data collection.
  • Epidemiological investigation.
  • Whole genome sequencing (WGS) for strain characterization.

Main Results:

  • Identification of probable first cases of Candida auris in Romania.
  • Cases occurred across three hospitals in Bucharest between January and August 2022.
  • Clinical and epidemiological data were collected, alongside WGS data.

Conclusions:

  • The findings indicate the presence and spread of Candida auris in Romania.
  • Early detection and surveillance are crucial for managing C. auris outbreaks.
  • Further research is needed to understand the epidemiology and treatment of C. auris in the region.
Keywords:
Candida aurisHealthcare-associated infections

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