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Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
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Functional nanoparticle-enabled non-genetic neuromodulation.

Zhimin Zhang1,2, Yanling You1,2, Min Ge3,4

  • 1Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai, 200050, People's Republic of China.

Journal of Nanobiotechnology
|September 6, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces nano-neuromodulation, using nanoparticles to precisely control nerve activity non-invasively. It reviews recent advances in non-genetic nano-neuromodulation (non-genetic NNM) for nerve regulation and disease treatment.

Keywords:
Field responseIon channelsNanoparticlesNeurological diseasesNeuromodulation

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Area of Science:

  • Neuroscience
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Neuromodulation offers precise nerve regulation beyond traditional therapies.
  • Functionalized nanoparticles integrate neuroscience and nanomaterials for novel applications.

Purpose of the Study:

  • Define and summarize the emerging field of nano-neuromodulation.
  • Review recent developments in non-genetic nano-neuromodulation (non-genetic NNM) over the past decade.
  • Discuss challenges and future directions in non-genetic NNM.

Main Methods:

  • Nanosystems absorb external stimuli (light, sound, electric, magnetic).
  • Stimuli are transformed or trigger chemical reactions.
  • Regulate ion channels and ion migration in the nervous system.

Main Results:

  • Demonstrated non-invasive, remote, and spatiotemporally precise nerve regulation.
  • Highlighted diverse nanoparticle compositions, structures, and synthesis approaches.
  • Identified key mechanisms involving stimuli-sensitive ion channels.

Conclusions:

  • Non-genetic NNM is a promising field for nerve regulation and disease therapeutics.
  • Overcoming current obstacles will drive further progress.
  • Future developments hold significant potential for advancing neurological treatments.