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Corneal densitometry and associated factors in an elderly population
Alireza Hashemi1, Payam Nabovati2, Hassan Hashemi3
1Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
Clinical & Experimental Optometry
|September 7, 2023
Summary
This study establishes normative corneal optical density (COD) values for the elderly population in Tehran. Understanding these values and associated factors is crucial for accurate diagnosis in older adults.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Geriatric Eye Care
Background:
- Normative corneal optical density (COD) values are essential for diagnosing pathological corneal conditions.
- Previous research has not extensively detailed COD distribution in elderly populations.
Purpose of the Study:
- To determine the distribution of corneal optical density (COD) in an elderly population (≥60 years).
- To identify factors associated with COD in this demographic.
Main Methods:
- A cross-sectional, population-based study was conducted in Tehran, Iran, involving 2068 elderly individuals (3633 eyes).
- Corneal densitometry was measured using Pentacam HR, with generalized estimating equation (GEE) models used for analysis.
- Participants underwent comprehensive ocular examinations.
Main Results:
- The mean entire COD was 21.96 ± 4.45 greyscale units (GSU).
- Significant differences in COD were observed across corneal layers and annular zones (p < 0.001).
- COD showed direct associations with age, central corneal thickness, and mean keratometry; inverse associations with female sex, anterior chamber depth, white-to-white distance, and corneal volume.
Conclusions:
- The study provides reference normative COD values for older adults.
- Associated factors of COD must be considered to prevent misinterpreting physiological changes as pathological conditions.
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