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Persistent Apoptotic Enteropathy in an Individual With Marginal Cell Lymphoma
Kyle Yuquimpo1, Piyush Nathani1, Harsh Patel1
1Division of Gastroenterology, Hepatology, & Motility, University of Kansas Medical Center, Kansas City, KS.
ACG Case Reports Journal
|September 7, 2023
Summary
A rare case of apoptotic enteropathy causing chronic diarrhea persisted a year after lymphoma treatment. The exact cause remained unknown despite remission, highlighting a potential long-term complication.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Apoptotic enteropathy, characterized by increased crypt apoptosis, is linked to diarrhea and has diverse known causes.
- These causes include immunodeficiency, autoimmune conditions, infections, hereditary factors, and various cancer therapies like checkpoint inhibitors and immunosuppressants.
Observation:
- This report details an exceptionally rare case of a patient with marginal cell lymphoma experiencing severe, chronic, and relapsing diarrhea.
- The patient presented with persistent apoptotic enteropathy, even a year after achieving hematological remission and discontinuing treatment with bendamustine, rituximab, and obinutuzumab.
Findings:
- Despite extensive investigation, the etiology of the apoptotic enteropathy remained unknown in this patient.
- The persistent gastrointestinal symptoms occurred despite complete remission of the underlying lymphoma and cessation of therapy.
Implications:
- This case highlights a potential, previously unrecognized long-term complication of specific cancer therapies.
- Further research is needed to understand the mechanisms and long-term effects of apoptotic enteropathy in patients treated for hematological malignancies.
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