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Updated: Aug 8, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Patch closure of aortic annulus mycotic aneurysms
Abstract:
Twenty-three patients with bacterial endocarditis and mycotic aneurysms of the aortic annulus were treated between 1978 and 1985. There were 18 men and 5 women ranging from 24 to 72 years old. All patients had congestive heart failure and positive blood cultures as a complication of the endocarditis and were in New York Heart Association (NYHA) Functional Class III or IV. The aneurysm complicated late prosthetic valve endocarditis in 7 patients and native valve endocarditis in 16. The most common infecting organisms were streptococci (12 patients) and staphylococci (7 patients). The noncoronary sinus was the most frequent site for aneurysm formation. Following debridement of the abscess cavity, the orifice of the aneurysm was closed with a patch of Dacron in 20 patients and autologous pericardium in 3. A prosthetic valve (18 bioprosthetic and 5 mechanical) was secured to the noninfected portion of the native annulus and to the patch at the level of annulus. There were 3 deaths, 1 perioperative and 2 late, each without evidence of residual infection or aortic insufficiency. There are 20 late survivors (87%). After a mean follow-up of 1 year, all patients are in NYHA Functional Class I. Patch closure of mycotic aneurysms involving the aortic annulus permits aggressive debridement of the abscess cavity and affords closure of the orifice without tension. The prosthetic valve can be seated at the level of the native annulus, thus avoiding complicated reconstructive procedures of the aortic root and coronary arteries. This technique is an effective alternative in selected cases of mycotic aneurysms involving the aortic annulus.
Insights
This study shows that patch closure of mycotic aneurysms in the aortic annulus is an effective treatment, leading to good outcomes for patients with bacterial endocarditis.
Area of Science:
- Cardiovascular Surgery
- Infectious Diseases
- Cardiac Surgery
Background:
- Mycotic aneurysms of the aortic annulus are serious complications of bacterial endocarditis.
- Patients often present with severe symptoms like congestive heart failure and are in advanced NYHA functional classes.
Purpose of the Study:
- To evaluate the effectiveness of a surgical technique for treating mycotic aneurysms of the aortic annulus.
- To assess the outcomes and long-term survival of patients undergoing this procedure.
Main Methods:
- Surgical debridement of the abscess cavity followed by closure of the aneurysm orifice with a Dacron or pericardial patch.
- Implantation of a prosthetic valve (bioprosthetic or mechanical) onto the native annulus and the closure patch.
- Treatment of 23 patients between 1978 and 1985 with bacterial endocarditis and aortic annulus mycotic aneurysms.
Main Results:
- A high success rate with 20 out of 23 patients surviving (87%) at a mean follow-up of 1 year.
- All survivors improved to NYHA Functional Class I, indicating significant functional recovery.
- Low mortality with only 3 deaths (1 perioperative, 2 late), none related to residual infection or aortic insufficiency.
Conclusions:
- Patch closure of mycotic aneurysms involving the aortic annulus is an effective surgical alternative.
- This technique allows for thorough debridement and tension-free closure, facilitating prosthetic valve placement at the native annulus level.
- It avoids complex aortic root and coronary artery reconstructions, offering a simpler approach for selected patients.
Related Concept Videos
Aortic Regurgitation III: Medical Management
Aneurysm I: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm III: Interprofessional Care

