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First Pass Effect01:12

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Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
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Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Nursing Clinical Information System (NCIS)
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Effect of a Commercial NCLEX-RN Preparation Product on First Time Pass Rates.

Lisa Scandale Lewis1, Tonya Willingham2, John Myers1

  • 1Duke University School of Nursing, Durham, NC, USA.

SAGE Open Nursing
|September 7, 2023
PubMed
Summary
This summary is machine-generated.

Commercial test preparation products did not significantly impact first-time National Council Licensure Exam-Registered Nurse (NCLEX-RN) pass rates. Instructor-guided use and individualized plans are recommended for nursing students preparing for the NCLEX-RN.

Keywords:
NCLEX-RNnursing educationstudent success

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Area of Science:

  • Nursing Education
  • Health Professions Licensure

Background:

  • The National Council Licensure Exam-Registered Nurse (NCLEX-RN) is critical for entry into the nursing profession.
  • First-time pass rates are key outcome measures for nursing programs and students.

Purpose of the Study:

  • To investigate the impact of a commercial NCLEX-RN test preparation product on first-time pass rates.
  • To compare demographic data and pass rates between students using a commercial product and a control group.

Main Methods:

  • Data collected from 688 first-time NCLEX-RN takers across six institutions.
  • Intervention group (n=396) received a 6-month subscription to a commercial test prep product.
  • Control group (n=292) did not use the product.

Main Results:

  • The intervention group had a higher proportion of students younger than 25 (55.8% vs. 34.6%, p < .001).
  • No significant differences in NCLEX-RN pass rates were observed between the intervention and control groups.
  • Demographics, apart from age, did not significantly differ between groups.

Conclusions:

  • Commercial NCLEX-RN test preparation products did not demonstrate a significant impact on first-time pass rates.
  • Recommends instructor-guided use of test preparation tools and individualized student support plans.
  • Emphasizes the need for comprehensive strategies to support nursing students' NCLEX-RN success.