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Prognostic value of hematological parameters in older adult patients with acute coronary syndrome undergoing coronary

Umar Hafiz Khan1, Murtaza Rashid Pala2, Imran Hafeez3

  • 1Geriatric Medicine, Department of Internal Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

Journal of Geriatric Cardiology : JGC
|September 7, 2023
PubMed

Insights

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can predict 30-day mortality in elderly patients with acute coronary syndrome (ACS). NLR is a more reliable predictor than total white blood cell count for risk classification.

Area of Science:

  • Geriatric Medicine
  • Cardiology
  • Hematology

Background:

  • Cardiovascular disease (CVD) significantly impacts geriatric patients.
  • Systemic inflammation is linked to age-related bone marrow changes and atherosclerosis.
  • Hematological biomarkers may predict mortality in elderly ACS patients.

Purpose of the Study:

  • To evaluate the predictive accuracy of hematological biomarkers for 30-day mortality in older adults with acute coronary syndrome (ACS).

Main Methods:

  • Prospective observational study of 601 elderly ACS patients (age > 60) undergoing percutaneous coronary intervention.
  • Assessed baseline hematological parameters and 30-day mortality.
  • Utilized logistic regression and receiver operating characteristic (ROC) curve analysis.

Main Results:

  • Mean age was 77 years. Mean NLR was 5.07; mean PLR was 108.65.
  • Univariate analysis showed NLR (OR=1.10) and PLR (OR=1.05) associated with mortality.
  • NLR predicted mortality with 68.1% accuracy; PLR with 65.7% accuracy. NLR was an independent predictor (OR=1.096).

Conclusions:

  • Neutrophil-lymphocyte ratio (NLR) is a valuable predictor of 30-day mortality in elderly ACS patients.
  • NLR demonstrates higher predictive accuracy compared to total white blood cell count.
  • NLR is recommended for risk stratification in geriatric ACS patients.
Abstract

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