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Updated: Jul 17, 2025
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
Wound infection in robotic-assisted radical prostatectomy compared with retropubic radical prostate surgery: A
Wei Zhu1, Lingfeng Wu1, Wenhua Xie1
1The Department of Urology, the First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, Zhejiang, China.
Abstract:
A meta-analysis investigation was executed to measure the wound infection (WI) in robotic-assisted radical prostatectomy (RRP) compared with retropubic radical prostate surgery (RRPS). A comprehensive literature investigation till February 2023 was applied, and 1197 interrelated investigations were reviewed. The 19 chosen investigations enclosed 107 153 individuals with prostate cancer (PC) at the starting point. 72 008 of them were utilising RRP, and 35 145 were utilising RRPS. Odds ratio (OR) in addition to 95% confidence intervals (CIs) was utilised to compute the value of the WI in RRP compared with RRPS by the dichotomous approaches and a fixed or random model. RRP had significantly lower surgical site wound infection (SSWI) (OR, 0.33; 95% CI, 0.21-0.52, P < .001) and infected lymphoceles (ILs) (OR, 0.45; 95% CI, 0.22-0.92, P = .03) compared with RRPS in individuals with PC. RRP had significantly lower SSWI and ILs compared with RRPS in individuals with PC. However, care must be exercised when dealing with its values because of the low sample size of some of the nominated investigations for the meta-analysis.
Insights
Robotic-assisted radical prostatectomy (RRP) significantly reduces surgical site wound infections and infected lymphoceles compared to retropubic radical prostate surgery (RRPS) in prostate cancer patients. Further research is needed due to sample size limitations in some studies.
Area of Science:
- Urology
- Surgical Oncology
- Evidence-Based Medicine
Background:
- Prostate cancer treatment often involves radical prostatectomy.
- Comparing surgical techniques like robotic-assisted radical prostatectomy (RRP) and retropubic radical prostate surgery (RRPS) is crucial for patient outcomes.
- Wound infection (WI) is a significant complication following prostatectomy.
Approach:
- A meta-analysis was conducted to compare wound infection rates between RRP and RRPS.
- Literature search until February 2023 identified 19 relevant studies.
- Data from 107,153 patients (72,008 RRP, 35,145 RRPS) were analyzed using odds ratios and confidence intervals.
Key Points:
- Robotic-assisted radical prostatectomy (RRP) demonstrated significantly lower surgical site wound infection (SSWI) rates compared to retropubic radical prostate surgery (RRPS).
- RRP also showed significantly lower rates of infected lymphoceles (ILs) compared to RRPS.
- Odds ratios indicated a substantial reduction in SSWI (OR, 0.33) and ILs (OR, 0.45) with RRP.
Conclusions:
- Robotic-assisted radical prostatectomy is associated with reduced wound infection complications compared to traditional retropubic surgery for prostate cancer.
- The findings suggest a potential benefit of RRP in minimizing surgical site infections and infected lymphoceles.
- Caution is advised when interpreting results due to the low sample size in some included studies for meta-analysis.
