Cytomegaly in benign ovarian cysts

We report two cases of benign ovarian cysts that revealed cytomegaly of the epithelial lining cells. One case was a large solitary luteinized follicle cyst of pregnancy and puerperium. The other case was an endometrial cyst. Changes in the cells included marked pleomorphism and hyperchromasia of the nuclei, large amounts of cytoplasm, and lack of mitotic figures. We ascribed these cellular features to hormonal effects and stress the importance of recognizing such changes and differentiating them from malignancy.