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Patients' Perceptions of Biosimilars: A Systematic Review
Qiyou Wu1, Zhitao Wang1, Xin Wang1
1School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Summary
Most patients are satisfied with biosimilar treatments, but a lack of knowledge about clinical effects and regulatory pathways impacts their perceptions. Educating healthcare professionals is key to improving patient understanding and acceptance of biosimilars.
Area of Science:
- Pharmacoeconomics and Patient Outcomes
- Drug Regulation and Policy
- Health Services Research
Background:
- Patient perceptions significantly influence the uptake and adherence to biosimilar medications.
- Understanding patient attitudes and knowledge gaps is crucial for effective biosimilar implementation strategies.
Approach:
- A systematic review was conducted, analyzing 43 studies published between 2018 and 2022.
- Studies were screened across multiple databases (PubMed, Embase, Web of Science, etc.) and quality-assessed using Joanna Briggs Institute tools.
- Included studies comprised quantitative, quasi-experimental, and qualitative designs, with sample sizes ranging from 9 to 6554 patients.
Key Points:
- The majority of patients reported satisfaction with biosimilar treatments.
- Patient knowledge regarding biosimilars was generally limited (familiarity ranging from 6-51%).
- Concerns about clinical efficacy and regulatory approval negatively impacted patient attitudes, while price advantages had mixed effects.
- Physicians, pharmacists, and regulatory bodies were identified as primary information sources, yet patient-provider communication gaps were noted.
Conclusions:
- While patient satisfaction with biosimilars is high, limited knowledge and specific concerns persist.
- Addressing doubts about clinical effects and regulatory pathways through enhanced healthcare professional education is essential.
- Improved communication from healthcare providers is vital to bridge knowledge gaps and foster informed patient decision-making regarding biosimilars.
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