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Bottom-Up Synthesis of Multicompartmentalized Microreactors for Continuous Flow Catalysis
Ruipeng Hao1, Ming Zhang1, Danping Tian1
1Shanxi Key Laboratory of Coal-based Value-added Chemicals Green Catalysis Synthesis, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China.
Journal of the American Chemical Society
|September 7, 2023
Summary
Researchers developed stable, liquid-containing microreactors for continuous flow catalysis. This biomimetic system enables efficient biocatalysis and chemo-enzymatic reactions with long-term operational stability.
Area of Science:
- Chemical Engineering
- Materials Science
- Biocatalysis
Background:
- Existing microreactors lack structural stability or liquid environments for biocatalysts.
- Continuous flow catalysis requires robust, compartmentalized systems.
Purpose of the Study:
- To develop stable, biomimetic multicompartmentalized liquid-containing microreactors (MLMs).
- To enable efficient continuous flow biocatalysis and cascade reactions.
Main Methods:
- Stepwise Pickering emulsification combined with interface-confined cross-linking.
- Bottom-up fabrication of MLMs with tunable interior architectures.
Main Results:
- Demonstrated robust MLMs with stable liquid microenvironments.
- Achieved 2000 h durability and 99% enantioselectivity in enzyme-catalyzed kinetic resolution.
- Showcased versatility in Pd-enzyme-cocatalyzed dynamic kinetic resolution of amines.
Conclusions:
- The developed MLMs offer a new platform for efficient biomimetic microreactors.
- This approach enables practical applications in continuous flow cascade catalysis.
- The strategy provides robust, tunable multicompartmentalized systems for diverse catalytic processes.
