Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inherited levator-medial rectus synkinesis

M P Pang, P H Zweifach, J Goodwin

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |October 1, 1986
    PubMed
    Summary

    This study identifies a rare, inherited form of levator-oculomotor synkinesis in two sisters. The condition, characterized by eyelid elevation during eye movement, appears to be autosomal dominant.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    NCGS like IBS 'type' symptoms is a diagnosis of exclusion.

    Nutrition journal·2021
    Same author

    Quantitative MRI: Defining repeatability, reproducibility and accuracy for prostate cancer imaging biomarker development.

    Magnetic resonance imaging·2021
    Same author

    Worsening pulmonary outcomes during sex reassignment therapy in a transgender female with cystic fibrosis (CF) and asthma/allergic bronchopulmonary aspergillosis: a case report.

    BMC pulmonary medicine·2020
    Same author

    'We've made the best of it. But we do not have a normal life': families' experiences of tuberous sclerosis complex and seizure management.

    Journal of intellectual disability research : JIDR·2019
    Same author

    The role of citizen science in addressing grand challenges in food and agriculture research.

    Proceedings. Biological sciences·2018
    Same author

    Understanding frames: A qualitative study of young people's experiences of using standing frames as part of postural management for cerebral palsy.

    Child: care, health and development·2017

    Area of Science:

    • Ophthalmology
    • Genetics
    • Neuro-ophthalmology

    Background:

    • Levator-oculomotor synkinesis is a rare condition affecting eyelid and eye muscle coordination.
    • Congenital and inherited forms are exceptionally uncommon, with limited prior documentation.

    Observation:

    • Two sisters presented with bilateral levator-oculomotor synkinesis, specifically left upper eyelid retraction on adduction.
    • Symptoms included significant lid elevation during adduction and depression, with mild ptosis in one patient during abduction.
    • No history of trauma, surgery, or diplopia was reported, and visual acuity remained good.

    Findings:

    • The affected individuals exhibited consistent patterns of eyelid retraction linked to specific eye movements.
    • A family history spanning three generations suggested a strong genetic component, pointing towards autosomal-dominant inheritance.
    • This represents a novel presentation of congenital, inherited levator-oculomotor synkinesis.

    Implications:

    • This familial case expands the known spectrum of levator-oculomotor synkinesis.
    • Understanding the genetic basis may aid in diagnosing and managing similar inherited ocular motility disorders.
    • Further research into the genetic underpinnings of synkinesis is warranted.

    Related Experiment Videos