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Updated: Jul 17, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
[Introduction of treatments for heart failure and reduced ejection fraction under 50 % : In-hospital optimization
Clément Charbonnel1, Annabelle Jagu1, Claire Vannier1
1Service de Cardiologie, Groupe Hospitalier Paris Saint Joseph, Paris, France.
Abstract:
Recent international guidelines recommend rapid initiation and titration of basic treatments of heart failure but do not explain how to achieve this goal. Despite these recommendations, implementation of treatment in daily practice is poor. This may be partly explained by the profile of the patients (frailty, comorbidities), safety considerations and tolerability issues related to kydney function, low blood pressure or heart rate and hyperkalaemia. In this special article, we intended to help the physician, through an algorithmic approach, to quickly and safely introduce guideline-directed medical therapy in the field of heart failure with ejection fraction under 50%.
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