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Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

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Related Experiment Video

Updated: Jul 17, 2025

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Published on: November 9, 2018

A new way to mitigate pathological Tau?

Asmita Ghosh¹, Christine Vande Velde¹

¹Department of Neurosciences, Université de Montréal, Montreal, QC H3C 3J7, Canada; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada.

|September 7, 2023

Summary

The RNA-binding protein G3BP2 interacts with Tau in human neurons and Alzheimer

Area of Science:

Neuroscience
Molecular Biology
Neurodegenerative Diseases

Background:

Tau pathology is a hallmark of Alzheimer's disease.
The role of RNA-binding proteins in neurodegeneration is increasingly recognized.

Purpose of the Study:

To investigate the interaction between G3BP2 and Tau.
To explore the potential role of G3BP2 in Alzheimer's disease pathogenesis.

Main Methods:

Immunohistochemistry in human brain tissue.
Co-immunoprecipitation assays.
Analysis of patient-derived neurons.

Main Results:

G3BP2 was found to interact with Tau in human neurons.
This interaction was observed in brain tissue from Alzheimer's disease patients.

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Last Updated: Jul 17, 2025

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

Published on: November 9, 2018

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An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

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Published on: May 23, 2019

G3BP2 may play a role in Tau aggregation or propagation.

Conclusions:

G3BP2 is a novel interacting partner of Tau in the context of Alzheimer's disease.
Targeting the G3BP2-Tau interaction could offer a new therapeutic strategy for Alzheimer's disease and other Tauopathies.