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Updated: Jul 17, 2025

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
Published on: August 24, 2017
Locus of control: How the brain gives up when failure is taken for granted
Joseph M Villarin1, Christoph Kellendonk2
1Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Abstract:
After repeatedly failing to get out of a stressful, uncontrollable environment, mice switch from escape behavior to inactivity. In this issue of Neuron, Li et al. identify a circuit involving noradrenergic projections from the locus coeruleus to GABAergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior.
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