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Updated: Jul 17, 2025

Gastrointestinal Motility Monitor GIMM

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

Gastroparesis: time for a paradigm change.

Brian E Lacy¹, Journey L Wise², David J Cangemi¹

¹Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Jacksonville, Florida.

Current Opinion in Gastroenterology

|September 7, 2023

Summary

Gastroparesis (GP) is often misdiagnosed. Accurate diagnosis requires proper gastric emptying studies, and treatment should address global symptoms, potentially reflecting gut-brain dysfunction.

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Area of Science:

Gastroenterology
Neurogastroenterology
Gut-Brain Axis Research

Background:

Gastroparesis (GP) is characterized by symptoms like nausea, vomiting, and delayed gastric emptying without obstruction.
Current treatment options for GP are limited, with only one FDA-approved medication.

Approach:

Review of four decades of GP trials to assess placebo effects and study design.
Analysis of diagnostic accuracy, including proper gastric emptying study protocols.
Exploration of GP as a potential disorder of gut-brain interaction.

Key Points:

GP is frequently over-diagnosed and misdiagnosed.
Accurate diagnosis hinges on rigorous gastric emptying studies and precise interpretation.
Emerging therapies focus on pyloric modulation.

Conclusions:

The diagnostic and treatment paradigm for gastroparesis requires significant revision.
Future research should emphasize longer, well-defined studies and consider the gut-brain axis.
Treatment should shift towards managing global symptoms of this chronic condition.