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Updated: Jul 17, 2025
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Analyzing Supercomplexes of the Mitochondrial Electron Transport Chain with Native Electrophoresis, In-gel Assays, and Electroelution
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Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review
Daan H H M Viering1, Lars Vermeltfoort1, René J M Bindels1
1Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Journal of the American Society of Nephrology : JASN
|September 7, 2023
Summary
Mitochondrial cytopathies frequently cause electrolyte disorders, often as initial symptoms. This highlights the importance of considering mitochondrial disease in patients with unexplained electrolyte imbalances.
Area of Science:
- Biochemistry and Molecular Biology
- Nephrology
- Genetics
Background:
- Kidney electrolyte reabsorption is energy-intensive, relying on high mitochondrial density in tubular cells.
- Electrolyte disorders are increasingly recognized as primary manifestations of mitochondrial cytopathies.
- The prevalence and mechanisms of these electrolyte disturbances remain largely unknown.
Conclusions:
- Mitochondrial diseases warrant consideration in the differential diagnosis of unexplained electrolyte disorders.
- Clinicians should maintain awareness of potential electrolyte abnormalities in individuals with known mitochondrial conditions.
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