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Etomidate in the treatment of Cushing syndrome
N Vergara Molina1, N Ruiz Andrés2, N Casas Martín1
1Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain.
Abstract:
Cushing syndrome is a metabolic disease caused by chronic exposure to high levels of glucocorticoids. It can present as an endocrine emergency due to a rapid increase in circulating cortisol leading to increased risk of cardiovascular disease and infection. Etomidate rapidly reduces plasma cortisol levels by inhibiting the action of 11β-hidroxilase. We report the case of a patient with severe hypercortisolaemia accompanied by metabolic and psychiatric disorders in whom administration of etomidate reduced preoperative levels of cortisol.
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