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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

3.6K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
3.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Adult Stem Cells01:33

Adult Stem Cells

30.2K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
30.2K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

4.9K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.9K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Updated: Jul 17, 2025

Derivation of Human Embryonic Stem Cells by Immunosurgery
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Derivation of Human Embryonic Stem Cells by Immunosurgery

Published on: December 13, 2007

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Introduction to stem cells.

Zeyu Tian1, Tao Yu1, Jun Liu1

  • 1State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.

Progress in Molecular Biology and Translational Science
|September 7, 2023
PubMed
Summary
This summary is machine-generated.

Stem cells possess self-renewal and differentiation abilities, crucial for tissue regeneration. This review covers stem cell types, including human pluripotent stem cells (hPSCs) like embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), and their therapeutic potential.

Keywords:
Adult stem cellsHuman pluripotent stem cellsRegenerative medicineStem cell therapy

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Area of Science:

  • * Regenerative Medicine and Developmental Biology: Exploring the fundamental properties of stem cells.

Background:

  • * Stem cells are defined by their self-renewal and differentiation capacities.
  • * Human pluripotent stem cells (hPSCs) encompass embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs).
  • * Adult stem cells are tissue-specific and can be multipotent or unipotent.

Approach:

  • * Review of the historical context, definitions, and classifications of stem cells.
  • * Discussion on the derivation and differentiation potential of hPSCs from embryonic and reprogrammed somatic sources.
  • * Examination of adult stem cell characteristics and their role in tissue maintenance.

Key Points:

  • * Pluripotent stem cells differentiate into all three germ layers: endoderm, mesoderm, and ectoderm.
  • * Induced pluripotent stem cells (hiPSCs) are generated by reprogramming somatic cells.
  • * Stem cell properties are essential for understanding tissue development and repair.

Conclusions:

  • * Stem cells hold significant promise for cell therapy, offering potential for tissue and organ regeneration.
  • * Understanding stem cell biology is critical for advancing regenerative medicine.
  • * The review provides a comprehensive overview of stem cell types and their applications.