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Updated: Jul 17, 2025
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Effect and mechanism of microRNAs on various diabetic wound local cells
Hongjie Li1,2, Shengyu Jing1,2, Hongbo Xu1
1Department of Vascular Surgery, The Third Xiangya Hospital of Central South University, Changsha, China.
Abstract:
The difficulty of wound healing in diabetes mellitus has long been regarded as a thorny problem in the medical field. One of the important reasons is the abnormal function of wound-related cells. A large number of recent studies have shown that microRNA (miR), a noncoding RNA that exists in eukaryotic cells, is closely linked to the functions of various cells in diabetic wound, and ultimately affects the healing of wound. This paper establishes for the first time the connection between miR and wound healing from the cellular perspective and summarizes the effects of various miRs on one or more kinds of wound cells, including their targets and related mechanisms. The abnormal expression of miRs in the wound has certain value for the early diagnosis of diabetic wounds. Moreover, it seems that correcting miRs that are abnormal expressed in the wound or artificially adding miRs that can promote wound healing has an essential therapeutic value.
Insights
MicroRNAs (miRs) are key to diabetic wound healing by regulating cell function. Targeting abnormal miRs offers diagnostic and therapeutic potential for these complex wounds.
Area of Science:
- Biomedical Science
- Molecular Biology
- Wound Healing Research
Background:
- Diabetic wound healing is a significant clinical challenge.
- Abnormal function of wound-related cells contributes to poor healing.
- MicroRNAs (miRs) are implicated in cellular processes affecting wound repair.
Purpose of the Study:
- To establish the cellular link between microRNAs and diabetic wound healing.
- To summarize the roles of various miRs in diabetic wound cells, their targets, and mechanisms.
- To explore the diagnostic and therapeutic potential of miRs in diabetic wounds.
Main Methods:
- Literature review focusing on microRNA research in diabetic wound healing.
- Analysis of studies detailing microRNA effects on wound cells.
- Identification of microRNA targets and regulatory mechanisms.
Main Results:
- MicroRNAs (miRs) significantly influence the function of various cells involved in diabetic wound healing.
- Specific miRs have been identified with roles in regulating cellular processes critical for repair.
- Abnormal miR expression patterns in wounds correlate with diagnostic potential.
Conclusions:
- MicroRNAs are crucial regulators of cellular function in diabetic wound healing.
- Dysregulated miRs present opportunities for early diagnosis of diabetic wounds.
- Modulating microRNA levels holds therapeutic promise for improving diabetic wound healing.
