Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Respiration01:24

Factors Affecting Respiration

5.2K
Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
5.2K
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

19.4K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
19.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

269
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
269
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

60.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.4K
Chemical Factors Affecting Respiration Centers01:31

Chemical Factors Affecting Respiration Centers

1.2K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperferritinemia in hospitalized children with dengue-a prospective observational study.

Journal of tropical pediatrics·2026
Same author

Systems Pharmacology and Pharmaco-Transcriptomic Insights into Bauhinia variegata for Polycystic Ovary Syndrome Management.

Current pharmaceutical design·2026
Same author

Survival Following Paralytic Rabies Encephalomyelitis in a Toddler: Challenges in Confirmation of Diagnosis.

Indian journal of pediatrics·2026
Same author

Thrombin-PAR1 signaling regulates Topoisomerase 1 activity to bridge inflammation and breast cancer progression.

Cancer letters·2026
Same author

Linking fruit and stone morphology with germination and polyembryony in two mango genotypes, Olour and Kurukkan.

BMC plant biology·2026
Same author

Perception-performance gap in trainee-performed pediatric caudal epidural block: Ultrasound verification of accuracy and clinical success.

Saudi journal of anaesthesia·2026

Related Experiment Video

Updated: Jul 17, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.2K

Quantifying systemic molecular networks affected during high altitude de-acclimatization.

Subhojit Paul1, Shikha Jain1, Anamika Gangwar1

  • 1Peptide & Proteomics Division, Defence Institute of Physiology & Allied Sciences (DIPAS), Defence R&D Organization (DRDO), Timarpur, New Delhi, 110054, India.

Scientific Reports
|September 7, 2023
PubMed
Summary

Returning from high altitude causes de-acclimatization syndrome (HADAS) with symptoms like headache. This study used proteo-informatics to reveal HADAS impacts on lipid metabolism, inflammation, and coagulation, offering therapeutic insights.

More Related Videos

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.4K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

561

Related Experiment Videos

Last Updated: Jul 17, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.2K
Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
10:00

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

8.4K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

561

Area of Science:

  • Human physiology
  • Network biology
  • Proteomics

Background:

  • High altitude acclimatization and disease are well-studied.
  • Altitude de-acclimatization, or de-induction, and its associated symptoms are less understood.
  • Recent studies identify "high altitude de-acclimatization syndrome" (HADAS) with diverse clinical manifestations.

Purpose of the Study:

  • To investigate the computational omics and network biology of human plasma proteome during altitude de-acclimatization.
  • To analyze changes in plasma proteome and pathways after descent from high altitude.
  • To provide a framework for therapeutic strategies to alleviate HADAS symptoms.

Main Methods:

  • Quantitative proteo-informatics and network biology analysis of human plasma proteome.
  • Utilized STRING and IPA for analyzing protein networks and upstream regulators.
  • Investigated plasma proteome changes from day 7 post-arrival at altitude up to day 180 post-descent.

Main Results:

  • De-induction significantly affects lipid metabolism, inflammation, and the innate immune system.
  • Coagulation system pathways were also extensively impacted by altitude de-acclimatization.
  • Identified specific protein networks and upstream regulators involved in HADAS.

Conclusions:

  • Altitude de-acclimatization has profound effects on key physiological systems.
  • Therapeutic strategies for HADAS should target lipid metabolism, inflammatory signaling, and coagulation.
  • This study offers a novel conceptual framework for managing de-acclimatization.