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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy

Kaixin Yang1, Yinan Xiao1, Linghui Zhong1

  • 1RNA Oncology Group, School of Public Health, Lanzhou University, Lanzhou, 730000, People's Republic of China.

Cancer Gene Therapy
|September 7, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial gene regulators implicated in cancer. This review highlights their role in the p53 pathway, offering potential biomarkers and therapeutic targets for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
  • Dysregulation of lncRNAs is linked to various diseases, notably cancer.
  • The p53 network is a critical tumor suppressor pathway in human malignancies.

Purpose of the Study:

  • To review the current understanding of lncRNAs in p53-related functions.
  • To elucidate how altered lncRNAs contribute to cancer initiation and progression.
  • To explore the relationship between lncRNAs and p53 pathway genes.

Main Methods:

  • Literature review of current research on lncRNAs and the p53 pathway.
  • Analysis of lncRNA involvement in p53-mediated gene regulation.
  • Discussion of lncRNA associations with upstream and downstream p53 targets.

Main Results:

  • lncRNAs significantly influence p53-mediated tumor suppression.
  • Altered lncRNA expression patterns are associated with cancer development.
  • lncRNAs interact with p53 pathway components, affecting cellular proliferation.

Conclusions:

  • lncRNAs are integral to the p53 signaling network in cancer.
  • lncRNAs represent potential biomarkers for cancer diagnosis and prognosis.
  • Targeting lncRNAs offers a promising therapeutic strategy for cancer treatment.

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