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Published on: September 30, 2021
Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and
Xiujuan Tan1, Chunfeng Liu1, Lingling Sun2
1Department of Intervention Chemotherapy, Zibo First Hospital, Zibo, China.
Abstract:
The aim of this systematic review and meta-analysis was to compile the data examining the association between the CTLA4 + 49 A/G polymorphism and the risk for HCC. Multiple databases were systematically searched for eligible studies and the pooled odds ratios (ORs) were generated using five genetic models. Pooled data from 11 studies with 3,055 HCC patients and 3,450 controls found no statistically significant association between the polymorphism and HCC risk, both overall and in subgroup analyses. In conclusion, the current meta-analysis shows that the CTLA4 + 49 A/G polymorphism is not significantly associated with the risk of developing HCC.
