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Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Current practices in islet cell autotransplantation.

Melissa E Chen¹, Chirag S Desai¹

¹Department of Surgery, University of North Carolina, Chapel Hill, NC, USA.

Expert Review of Endocrinology & Metabolism

|September 8, 2023

Summary

Total pancreatectomy with islet cell autotransplantation offers significant benefits for chronic pancreatitis patients. This procedure improves quality of life and prevents difficult-to-manage diabetes, enhancing patient outcomes.

Keywords:

Chronic pancreatitis islet cell autotransplantation recurrent acute pancreatitis total pancreatectomy

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Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

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Published on: July 23, 2017

Inguinal Subcutaneous White Adipose Tissue ISWAT Transplantation Model of Murine Islets

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A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Area of Science:

Gastroenterology and Transplant Surgery
Endocrinology

Background:

Chronic pancreatitis leads to exocrine/endocrine insufficiency, chronic pain, and poor quality of life.
Medical and endoscopic therapies are primary treatments; surgery, especially total pancreatectomy, was historically limited due to managing resulting diabetes (type 3C).

Purpose of the Study:

To review current practices in islet cell autotransplantation following total pancreatectomy.
To detail patient selection, preoperative management, surgical techniques, and postoperative care.

Main Methods:

Review of current practices in islet cell autotransplantation.
Description of patient evaluation, surgical approach, and postoperative management.

Main Results:

Total pancreatectomy with islet cell autotransplantation can mitigate brittle type 3C diabetes.
The procedure helps prevent mortality from severe hypoglycemia and improves quality of life.

Conclusions:

Islet cell autotransplantation after total pancreatectomy is a viable option for select chronic pancreatitis patients.
Recent data support the safety and long-term benefits of this surgical approach.