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Updated: Jul 17, 2025
13:25
Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
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Acute renal failure during cisplatin-based chemotherapy: A prospective monocentric study
Wala Ben Kridis1, Mayssa Lajnef1, Afef Khanfir1
1Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Summary
Acute renal failure (ARF) is a common side effect of cisplatin chemotherapy, occurring in 30% of patients. Higher cumulative doses of cisplatin (≥330 mg/m²) are linked to an increased risk of developing ARF.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Cisplatin is a cornerstone antineoplastic agent for solid cancers.
- Renal toxicity is a significant concern with cisplatin-based chemotherapy.
- Understanding the prevalence and risk factors for cisplatin-induced acute renal failure (ARF) is crucial.
Purpose of the Study:
- To determine the incidence of ARF in patients undergoing cisplatin chemotherapy.
- To identify factors associated with the development of cisplatin-related renal toxicity.
Main Methods:
- Prospective study over 6 months.
- Inclusion of patients with histologically confirmed solid cancer receiving cisplatin.
- Renal function assessed via creatinine clearance at baseline, pre-cycle, and at 3 and 6 months.
Main Results:
- 30% of 40 patients developed ARF, predominantly grade 1.
- ARF occurred after a mean cumulative dose of 208 mg/m².
- Aggravating factors included digestive toxicity (67%) and tumor-related urinary obstruction (8%).
- Increased cisplatin cycle number (>3) and cumulative dose (≥330 mg/m²) were associated with renal toxicity (p=0.04).
Conclusions:
- Cisplatin-induced ARF is dose-dependent, with most cases being low-grade.
- A cumulative cisplatin dose exceeding 330 mg/m² significantly increases the risk of ARF.
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