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Radiation-associated Arrhythmias: Putative Pathophysiological Mechanisms, Prevalence, Screening and Management
Rohil Bedi1, Ali Ahmad1, Piotr Horbal1,2
1Department of Internal Medicine, Saint Louis University School of Medicine St Louis, Missouri, US.
Arrhythmia & Electrophysiology Review
|September 8, 2023
Summary
Radiation therapy for chest cancers can cause long-term heart problems, including arrhythmias. This overview covers the causes, frequency, and treatment of these radiation-associated heart rhythm issues.
Area of Science:
- Cardiology
- Oncology
- Radiotherapy
Background:
- Radiation therapy for chest cancers is linked to cardiovascular disease.
- Improved cancer survival leads to delayed detection of radiation-associated cardiovascular disease.
- Radiation-associated arrhythmias are a significant concern years after treatment.
Purpose of the Study:
- To provide an overview of radiation-associated arrhythmias.
- To discuss the pathophysiology, prevalence, and management of these conditions.
Main Methods:
- Literature review of radiation-associated cardiovascular disease.
- Focus on arrhythmias, including bradyarrhythmias and tachyarrhythmias.
- Examination of autonomic dysfunction.
Main Results:
- Radiation-associated cardiovascular disease is an increasing problem.
- Arrhythmias manifest years to decades post-radiotherapy.
- Management strategies are being developed.
Conclusions:
- Radiation-associated arrhythmias require ongoing attention.
- Understanding pathophysiology is key to management.
- Multidisciplinary care is essential for cancer survivors.
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