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An Updated Systematic Review on Remdesivir's Safety and Efficacy in Patients Afflicted With COVID-19

Mohamed Yasir1, Chetan Reddy Lankala2, Pravin Kalyankar3

  • 1Division of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Cureus
|September 8, 2023
PubMed

Insights

Remdesivir shows potential as a safe and effective treatment for coronavirus disease 2019 (COVID-19), particularly in early stages. However, its safety in patients with COVID-19 complications requires further large-scale investigation.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • The COVID-19 pandemic placed immense pressure on global healthcare systems.
  • Remdesivir emerged as a key antiviral investigated for its efficacy and safety in treating COVID-19.
  • Understanding remdesivir's impact on disease progression, complications, and mortality is crucial.

Purpose of the Study:

  • To conduct an updated literature assessment on the efficacy and safety of remdesivir for COVID-19 treatment.
  • To synthesize findings from various studies evaluating remdesivir's clinical impact.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Web of Science, Cochrane, and Scopus.
  • Included studies published between 2019 and September 20, 2022, focusing on remdesivir's efficacy and safety.
  • Clinical improvement was the primary outcome measure for assessing treatment effectiveness.

Main Results:

  • Seventeen studies were identified and analyzed.
  • Eleven studies supported the efficacy of remdesivir in treating COVID-19.
  • Six studies did not find a statistically significant difference in clinical improvement with remdesivir use.

Conclusions:

  • Remdesivir demonstrates potential as a safe and effective antiviral for COVID-19, especially when administered early in the disease course.
  • Evidence suggests clinical improvement in patients treated with remdesivir.
  • Further large-scale studies are needed to clarify remdesivir's safety profile in patients experiencing COVID-19 complications.

Keywords:
antiviral drugscovid-19efficacyremdesivirsars-cov-2 treatment

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