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Readmission reasons of pediatric patients diagnosed with multisystem inflammatory syndrome after discharge
Ela Cem1, Elif Kıymet1, Elif Böncüoğlu1
1Department of Paediatric Infectious Diseases, University of Health Sciences, Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Türkiye.
Insights
Multisystem inflammatory syndrome in children (MIS-C) readmissions are uncommon, with fever being the most frequent cause. Close cardiac monitoring is crucial for children diagnosed with MIS-C post-infection.
Area of Science:
- Pediatric Infectious Diseases
- Pediatric Cardiology
- Critical Care Medicine
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition following SARS-CoV-2 infection.
- Limited data exists regarding the causes of MIS-C reactivation and indications for hospital readmission.
- Understanding readmission patterns is vital for optimizing post-discharge care and preventing complications.
Purpose of the Study:
- To investigate the conditions leading to readmission in children previously diagnosed with MIS-C.
- To identify specific indications for rehospitalization after initial MIS-C treatment.
- To evaluate the frequency and characteristics of MIS-C readmissions.
Main Methods:
- A single-center retrospective study included 95 pediatric patients diagnosed with MIS-C.
- Data was collected from November 2020 to December 2021.
- Patients rehospitalized for MIS-C were identified, and reasons for readmission were analyzed.
Main Results:
- Six out of 95 patients (6.3%) required rehospitalization.
- Fever was the primary reason for readmission in 50% of these cases.
- Other readmission indications included myocarditis, pneumonia, and post-traumatic pain syndrome.
Conclusions:
- While MIS-C reactivation was not directly observed, the study highlights the necessity of vigilant follow-up.
- Particular attention should be paid to potential cardiac complications in children recovering from MIS-C.
- Further research is warranted to elucidate long-term outcomes and specific management guidelines for MIS-C survivors.
Objectives:
There is no clear information in the literature about causes of reactivation of multisystem inflammatory syndrome in children (MIS-C) or indications for readmissions for MIS-C after discharge; as a result, the conditions that may develop after infection in children with MIS-C were discussed, and the reasons for hospitalization were screened.
Patients And Methods:
This single-center retrospective study was conducted with 95 patients (65 males, 30 females; mean age: 92.8±55.5 months; range, 5 to 17 months) between November 11, 2020, and December 30, 2021. Children who were rehospitalized in the study center after their discharge with the diagnosis of MIS-C were included in the study, and the indications for readmissions were evaluated.
Results:
During the study period, six (6.3%) patients (4 males, 2 females; median age: 114.5 months [interquartile range: 122 months]) had to be rehospitalized. Four of these patients had an underlying disease, while the other two were previously healthy children. Fever was the most common reason for readmissions in half of the patients, while the remaining patients were readmitted with the indications of myocarditis, pneumonia, and posttraumatic pain syndrome.
Conclusion:
Although no evidence for the reactivation of MIS-C was detected in patients in the literature, it should also be emphasized that close follow-up of these patients is a must, considering possible cardiac complications.
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