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Updated: Jul 17, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
Physical virology: how physics is enabling a better understanding of recent viral invaders
Ruana Cardoso-Lima1,2, Ralph Santos-Oliveira3,4, Pedro Filho Noronha Souza5,6
1Physics Department, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, São Luís, MA Brazil.
Abstract:
The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies' fundamental components work to counteract them. Determining the ultrastructure and nanomechanical characteristics of viruses from a physical standpoint helps categorize their mechanical characteristics, offers insight into new treatment options, and/or shows weak spots that can clarify methods for medication targeting. This study compiles the findings from studies on the ultrastructure and nanomechanical behavior of SARS-CoV-2, ZIKV (Zika virus), and CHIKV (Chikungunya virus) viral particles. With results that uncovered aspects of the organization and the spatial distribution of the proteins on the surface of the viral particle as well as the deformation response of the particles when applied a recurring loading force, this review aims to provide further discussion on the mechanical properties of viral particles at the nanoscale, offering new prospects that could be employed for designing strategies for the prevention and treatment of viral diseases.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s12551-023-01075-4.
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