Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...

Protein Folding

Protein Folding

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...

Conserved Binding Sites

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors controlling protein evolvability-at the molecular scale.

European biophysics journal : EBJ·2026

Same author

Physical principles underpinning molecular-level protein evolution.

European biophysics journal : EBJ·2025

Same author

The origin of mutational epistasis.

European biophysics journal : EBJ·2024

Same author

Analysis of proteins in the light of mutations.

European biophysics journal : EBJ·2024

Same author

Protein folding rate evolution upon mutations.

Biophysical reviews·2023

Same author

Rethinking the protein folding problem from a new perspective.

European biophysics journal : EBJ·2023

Same journal

Navigating the labyrinth of drugging the disordered.

Biophysical reviews·2026

Same journal

<i>Biophysical Reviews</i>: a forum for publication of review articles from the international biophysics community.

Biophysical reviews·2026

Same journal

Mitochondrial potassium channels: mitochondria-specific mechanism of regulation.

Biophysical reviews·2026

Same journal

Biomolecular condensates in living systems: from function to disease. What to do next.

Biophysical reviews·2026

Same journal

Astrocyte morphology: complex or trivial?

Biophysical reviews·2026

Same journal

Correction to: A quest for greater thermodynamic rigour in the quantitative characterization of protein self-association by direct assessment of sedimentation equilibrium distributions.

Biophysical reviews·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 17, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein structure prediction from the complementary science perspective.

¹IMASL-CONICET, Universidad Nacional de San Luis, Ejército de Los Andes 950, 5700 San Luis, Argentina.

Biophysical Reviews

|September 8, 2023

Summary

This summary is machine-generated.

Comparing planetary orbit prediction and protein structure determination reveals a common scientific method: observation, pattern recognition, and modeling. This suggests new approaches to understanding complex biological processes like protein folding.

Keywords:

History of science Leibniz and Kant Newton Philosophy Planetary orbits Protein folding

More Related Videos

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jul 17, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

Area of Science:

Interdisciplinary science
Computational biology
Astrophysics

Background:

Historically, predicting planetary orbits and protein structures were monumental challenges.
Both problems required centuries of scientific inquiry to solve.
A common methodological framework may underpin diverse scientific breakthroughs.

Purpose of the Study:

To identify shared principles in solving complex scientific problems.
To explore the potential of comparative analysis in scientific discovery.
To propose novel perspectives on protein folding based on historical parallels.

Main Methods:

Comparative analysis of historical scientific problem-solving approaches.
Examination of the resolution pathways for planetary orbit prediction and protein structure determination.
Inference of commonalities in scientific modeling and pattern recognition.

Main Results:

Identified a shared problem-solving trajectory: observation → pattern recognition → modeling.
Preliminary findings suggest complementary scientific approaches can yield new insights.
A novel perspective on protein folding may emerge from this comparative analysis.

Conclusions:

The resolution of seemingly disparate scientific problems can share fundamental methodologies.
Interdisciplinary insights, particularly from complementary sciences, are crucial for tackling complex challenges like protein folding.
Further research into commonalities could deepen our understanding of protein folding and other unsolved scientific mysteries.