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Updated: Jul 17, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
The use of angiotensin receptor blockers in dementia prevention
Jordana de Araujo Müller1, Laura Jacques Giacobe1, Vanise Grassi1
1Universidade do Vale do Taquari, Centro de Ciências Médicas, Lajeado RS, Brazil.
Abstract:
Alzheimer's disease (AD) and dementia are preventable and highly prevalent diseases, as is systemic arterial hypertension. Thus, it is speculated that angiotensin receptor blockers (ARBs) may be neuroprotective against AD.
Objective:
The aim of this study was to evaluate if the use of ARBs confers a neuroprotective effect on AD, through a systematic review.
Methods:
Studies published on Embase, LILACS, SciELO, and PubMed were evaluated. The selection of the studies included those that evaluated the use of antihypertensive drugs in individuals with a previous diagnosis of mild cognitive impairment. The data were extracted with the Cochrane Effective Practice and Organization of Care (EPOC) form. The risk of bias was evaluated by the EPOC "Risk of bias tool."
Results:
A total of 12 articles were identified, and 3 articles were selected. Two of them analyzed the use of ARB/ACEI versus other antihypertensives and the development of dementia.
Conclusion:
There is a tendency for ARBs to be superior to other antihypertensives in preventing dementia.
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