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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Mitral Stenosis I: Introduction01:22

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Related Experiment Video

Updated: Jul 17, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Decrease of left ventricular function measured by speckle-tracking echocardiography based on systemic lupus

Masita I Rustam1, Reni Ghrahani2, Dzulfikar D L Hakim3

  • 1Department of Child Health, Faculty of Medicine, Universitas Padjadjaran - Dr Hasan Sadikin General Hospital, Bandung, Indonesia.

Cardiology in the Young
|September 8, 2023
PubMed
Summary
This summary is machine-generated.

Pediatric systemic lupus erythematosus (SLE) patients with moderate disease activity show reduced left ventricular function compared to those with mild activity. Speckle-tracking echocardiography reveals subtle cardiac changes in moderate SLE activity.

Keywords:
EchocardiographyMEX-SLEDAIglobal longitudinal strainleft ventricular functionspeckle-tracking echocardiographysystemic lupus erythematosus

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Area of Science:

  • Pediatric Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Systemic lupus erythematosus (SLE) in children often presents aggressively.
  • Cardiac involvement in pediatric SLE can be subclinical.
  • Speckle-tracking echocardiography (STE) is a sensitive tool for detecting cardiac dysfunction.

Purpose of the Study:

  • To compare left ventricular (LV) function using STE in pediatric SLE patients with varying disease activity.
  • To identify differences in cardiac function based on disease severity.

Main Methods:

  • Cross-sectional study of 49 pediatric SLE patients.
  • Disease activity assessed using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI).
  • Conventional and speckle-tracking echocardiography performed.

Main Results:

  • Global longitudinal strain was significantly reduced in moderate SLE activity (-16.58) versus mild activity (-19.65).
  • Ejection fraction, fractional shortening, and E/A ratio did not differ significantly between mild and moderate activity groups.
  • 81.96% of subjects were female, with an average age of 15 years.

Conclusions:

  • Children with moderate SLE activity exhibit impaired left ventricular function compared to those with mild activity.
  • STE can detect subclinical cardiac dysfunction in pediatric SLE.
  • Disease activity is associated with alterations in myocardial strain.