Related Experiment Video

Updated: Jul 17, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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SHP2: A Pleiotropic Target at the Interface of Cancer and Its Microenvironment

Nicole M Sodir1, Gaurav Pathria2, Joanne I Adamkewicz3

  • 1Department of Translational Oncology, Genentech, South San Francisco, California.

Cancer Discovery
|September 8, 2023
PubMed

Insights

Protein phosphatase SHP2 (PTPN11) is a key target in cancer, impacting both tumor growth and the tumor microenvironment. SHP2 inhibitors offer dual benefits, inhibiting cancer intrinsically and extrinsically, and are promising combination agents.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • SHP2 (PTPN11) is a protein phosphatase regulating proliferative pathways in various cancers.
  • SHP2 also plays a critical role in modulating the tumor microenvironment.
  • This dual function positions SHP2 as a multifaceted target for cancer therapy.

Conclusions:

  • SHP2 is a critical regulator of cancer proliferation and the tumor microenvironment.
  • SHP2 inhibitors offer a promising therapeutic strategy, particularly in combination regimens.
  • Targeting SHP2 can enhance the depth and durability of responses to cancer therapy.

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