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Cost-per-Response Analysis of Pure Hypochlorous Acid Among Patients with Chronic Venous Leg Ulcers: A Health Economic
Jeffrey A Niezgoda1, Jonathan A Niezgoda, Kathleen M Niezgoda
1Jeffrey A. Niezgoda, MD, MAPWCA, CHWS, is President and Chief Marketing Officer, WebCME, Greendale, Wisconsin, USA. Jonathan A. Niezgoda, CHWS, is Student, University of Wisconsin, Milwaukee. Kathleen M. Niezgoda, RN, APNP, is Advanced Practice Nurse Practitioner, WebCME. Peter J. Mallow, PhD, is Associate Professor, Department of Health Services Administration, Xavier University, Cincinnati, Ohio. Acknowledgments: Peter J. Mallow is a paid consultant to URGO Medical North America. This research was funded by an URGO Medical North America investigator-led grant to Dr Niezgoda to cover the costs associated with the study. The authors have disclosed no other financial relationships related to this article. Submitted November 9, 2022; accepted in revised form February 10, 2023.
Objective:
To estimate the total cost-per-wound healing response (CPR) and the per-day CPR of patients with chronic leg ulcers treated with pure hypochlorous acid (pHA) as part of their overall would healing regimen.
Methods:
The authors developed a deterministic decision-tree model to estimate the incremental CPR for pHA. The analysis was performed using clinical data from a published single-arm prospective study. The outcome of interest was re-epithelialization at 90 days. Economic data for pHA were based on public prices of pHA per dressing change from the wound care center perspective. The following time points were assessed: 90, 60, and 30 days. Dressing changes occurred every 2.5 days. Sensitivity analysis was performed to gauge the robustness of the results.
Results:
A total of 31 patients (68% women) with 31 lesions (average age of wound, 29 months; range, 1-240 months) were included in the clinical study. Re-epithelialization occurred in 23 lesions (74%) at 90 days, 17 (55%) at 60 days, and 3 (10%) at 30 days. The total CPRs were $75.69, $68.27, and $193.44, and the per-day CPRs were $0.84, $1.13, and $6.45 at 90, 60, and 30 days, respectively. The sensitivity analysis revealed that CPRs ranged from $0.63 to $1.12 per day at 90 days.
Conclusions:
Incorporating pHA into standard wound healing protocols is a minimal added expense and may yield a substantial economic savings of $2,695 at 90 days.
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