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Published on: April 17, 2019
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET)
Gregory Kaltsas1, Thomas Walter2, Ulrich Knigge3
11st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Abstract:
The aim of the present guidance paper is to update the previous ENETS guidelines on well differentiated appendiceal neuroendocrine tumours (NET), providing practical guidance for the diagnosis and management of appendiceal NET (aNET); poorly differentiated neoplasms are dealt with in a separate guidance paper. This paper is structured on a question-answer format in order to also address controversial issues and areas where uncertainty regarding the management and follow-up of aNET exists. All recommendations are offered on the basis of the best available evidence, along with the authors' experiences in managing these neoplasms. Each recommendation for treatment will provide a level of evidence and grade of recommendation as per the GRADE system (adapted in Infectious Disease Society of United States Public Health Service grading system).
Insights
This guidance paper updates expert recommendations for diagnosing and managing well-differentiated appendiceal neuroendocrine tumors (aNET). It addresses uncertainties and controversial issues using the best available evidence and expert experience.
Area of Science:
- Gastroenterology
- Oncology
- Endocrinology
Background:
- Appendiceal neuroendocrine tumors (aNET) require updated diagnostic and management guidelines.
- Previous European Neuroendocrine Tumor Society (ENETS) guidelines need revision.
- Poorly differentiated neoplasms are addressed separately.
Purpose of the Study:
- To provide practical guidance for the diagnosis and management of well-differentiated appendiceal NET (aNET).
- To address controversial issues and areas of uncertainty in aNET management and follow-up.
- To update existing ENETS guidelines on aNET.
Main Methods:
- Guidance paper structured in a question-answer format.
- Recommendations based on the best available evidence.
- Inclusion of authors' clinical experience in managing aNET.
- Utilizing the GRADE system (adapted) for evidence and recommendation grading.
Main Results:
- Provides updated, practical guidance for aNET diagnosis and management.
- Clarifies recommendations for controversial and uncertain aspects of aNET care.
- Offers evidence-based and expert-opinion-driven recommendations.
Conclusions:
- The updated guidance offers a comprehensive resource for clinicians managing aNET.
- Addresses critical knowledge gaps and provides clear recommendations.
- Aims to improve patient outcomes through standardized, evidence-based care.
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