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Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

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Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
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Psychological Responses to Stress01:20

Psychological Responses to Stress

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Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
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The Trier Social Stress Test Protocol for Inducing Psychological Stress
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Mental stress objective screening for workers using urinary neurotransmitters.

Kazuhiro Tanabe1,2, Asaka Yokota1

  • 1Medical Solution Promotion Department, Medical Solution Segment, LSI Medience Corporation, Tokyo, Japan.

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Urinary neurotransmitters like dopamine can indicate high mental stress in workers. Lower levels of these compounds in urine may signal increased stress, aiding early detection and intervention for mental well-being.

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Area of Science:

  • Occupational Health
  • Neuroscience
  • Biochemistry

Background:

  • Mental disorders like depression and anxiety affect nearly 10% of the population.
  • High stress levels are a significant risk factor for developing mental health conditions.
  • Early detection and management of mental stress are crucial to prevent the onset of disorders.

Purpose of the Study:

  • To develop an objective screening test for quantifying mental stress in workers.
  • To enable early recognition and mitigation of stress before it leads to mental disorders.
  • To identify reliable biomarkers for mental stress.

Main Methods:

  • Collected urine samples from 100 healthy volunteers.
  • Administered the Brief Job Stress Questionnaire (BJSQ) to assess stress levels.
  • Analyzed six urinary neurotransmitters (dopamine, serotonin, 5-HIAA, GABA, HVA, VMA) using liquid chromatography-mass spectrometry.
  • Compared neurotransmitter levels between high-stress and low-stress groups.

Main Results:

  • Significantly lower levels of urinary dopamine and homovanillic acid (HVA) were observed in the high-stress group.
  • A stress index derived from neurotransmitter concentrations effectively identified individuals in the high-stress group.
  • Urinary neurotransmitter levels correlated with specific stress factors like dissatisfaction, fatigue, and worry.

Conclusions:

  • Urinary neurotransmitters show promise as objective indicators of underlying mental stress.
  • This research supports the development of screening tests for mental stress in workers.
  • Findings may inform the development of screening tools for individuals at risk of depression.