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Dual evolutionary modes in the bovine globin locus.

A M Brunner, J C Schimenti, C H Duncan

|September 9, 1986

Summary

Bovine globin pseudogenes evolved through gene duplication and conversion, transitioning from coupled to solitary evolution. Nonhomologies created barriers, influencing gene polymorphism distribution.

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Area of Science:

Genomics
Molecular Evolution

Background:

Bovine globin genes form a multigene family.
Pseudogenes play a role in gene family evolution.

Purpose of the Study:

Analyze bovine globin pseudogene sequences.
Understand the evolutionary mechanisms of globin gene families.

Main Methods:

Sequence analysis of five bovine globin pseudogenes.
Comparison with adult and fetal bovine globin genes.

Main Results:

Identified large-scale duplication and gene conversion as key evolutionary events.
Observed a transition from concerted to solitary evolution mediated by nonhomologies.
Found inhomogeneous distribution of allelic gene polymorphisms.

Conclusions:

Bovine globin pseudogenes evolved via duplication and gene conversion.
Nonhomologies acted as barriers, uncoupling genes from concerted evolution.
Recent pseudogene duplication likely interrupted interchromosomal gene conversion.

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