A modified QuEChERS method based on a reduced graphene oxide-coated melamine sponge for multiresidue analysis of
Baocheng Ji1, Lanrui Yang1, Chengyu Ren2
1School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, PR China; Henan Key Laboratory of Cold Chain Quality and Safety Control, Zhengzhou, PR China; Collaborative Innovation Center of Food Production and Safety, Henan Province, PR China; Key Laboratory of Cold Chain Food Processing and Safety Control (Zhengzhou University of Light Industry), Ministry of Education, Zhengzhou, PR China.
Abstract:
The development of different matrix adsorbents is a research focus in the multiresidue analysis of veterinary drugs in foods. In this study, a novel elastic matrix adsorbent based on a reduced graphene oxide-coated melamine sponge was prepared and applied in matrix purification for the simultaneous determination of 52 veterinary drugs in mutton by UPLC-MS/MS. Efficient and convenient matrix removal was achieved through simple soaking and squeezing. Good linearities with determination coefficients ≥0.999 and low matrix effects ≤±13% were obtained in the range of 10-500 μg·kg-1. The obtained recoveries ranged from 63.7% to 109.5% at three spiked levels (10, 50, and 100 μg·kg-1), with relative standard deviations ≤8.1%. Low LODs and LOQs were obtained in ranges of 0.02-2.0 μg·kg-1 and 0.05-5.0 μg·kg-1, respectively. Based on the comprehensive results, our developed method showed good applicability in the analysis of multiresidues in various foods.
