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Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Nano-enabled colorectal cancer therapy.

Qingqing Pan¹, Xi Fan², Li Xie¹

¹School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|September 8, 2023

Summary

Nanomedicine offers novel strategies for colorectal cancer (CRC) treatment, addressing challenges like drug resistance and recurrence. This review highlights advancements in targeted drug delivery, immunotherapy sensitization, and gut microbiota modulation for improved CRC outcomes.

Keywords:

Colorectal cancer Gut microbiota Immunotherapy Nanoscale drug delivery systems Therapy resistance

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Published on: March 25, 2019

Area of Science:

Oncology
Nanomedicine
Gastroenterology

Background:

Colorectal cancer (CRC) is a major global health challenge with limited treatment efficacy due to toxicity, resistance, and recurrence.
Conventional therapies (surgery, chemotherapy, radiotherapy) and recent advances (targeted therapy, immunotherapy) face significant limitations.
Emerging strategies involving gut microbiota modulation show promise for CRC prevention and treatment, influencing therapy efficacy and toxicity.

Purpose of the Study:

To provide a comprehensive review of nanomedicine-based treatments for colorectal cancer.
To highlight recent progress in oral and systemic drug delivery systems for CRC.
To discuss novel therapeutic strategies and future directions for addressing CRC challenges.

Main Methods:

Literature review focusing on nanomedicine applications in colorectal cancer.
Analysis of recent advancements in targeted and activatable drug delivery systems.
Synthesis of information on immunotherapy sensitization, anti-inflammation, and gut microbiota modulation.

Main Results:

Nanomedicine enables advanced drug delivery systems targeting colorectal tumors.
Novel strategies include nano-sensitized immunotherapy, anti-inflammatory approaches, and gut microbiota modulation.
Recent research addresses therapy resistance, metastasis, and recurrence in colorectal cancer using nanomedicine.

Conclusions:

Nanomedicine holds significant potential for developing innovative colorectal cancer therapies.
Targeted drug delivery and combination strategies are crucial for overcoming treatment resistance.
Further research into nanomedicine for CRC can lead to improved patient outcomes and reduced disease burden.