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Updated: Jul 16, 2025
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Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
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Convergent insights into intratumor heterogeneity
Claudia Manini1, Annick Laruelle2, André Rocha3
1Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy; Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy.
Trends in Cancer
|September 8, 2023
Summary
Highly aggressive clear cell renal cell carcinomas (CCRCCs) show low intratumor heterogeneity (ITH). Maintaining high ITH levels may slow cancer evolution and improve survival in these aggressive cancers.
Area of Science:
- Oncology
- Genomics
- Cancer Biology
Background:
- Clear cell renal cell carcinoma (CCRCC) is an aggressive cancer.
- Intratumor heterogeneity (ITH) is a key factor in cancer evolution and treatment resistance.
- Understanding the role of ITH in CCRCC is crucial for developing effective therapies.
Purpose of the Study:
- To investigate the relationship between ITH and the aggressiveness of clear cell renal cell carcinomas.
- To explore the potential of therapeutic strategies targeting ITH to improve patient outcomes.
Main Methods:
- Integration of mathematical modeling, conventional histology, and genomic data analysis.
- Assessment of ITH levels in highly aggressive CCRCC samples.
Main Results:
- Convergent evidence from mathematics, histology, and genomics confirms that highly aggressive CCRCCs exhibit low levels of ITH.
- This finding establishes a significant correlation between low ITH and tumor aggressiveness.
Conclusions:
- Low intratumor heterogeneity is a hallmark of highly aggressive clear cell renal cell carcinomas.
- Therapeutic strategies designed to maintain or increase ITH levels could represent a novel approach to slow cancer progression and enhance patient survival in CCRCC.
