Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Predicting Molecular Geometry02:27

Predicting Molecular Geometry

34.4K
VSEPR Theory for Determination of Electron Pair Geometries
34.4K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

79
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
79
Modeling and Similitude01:12

Modeling and Similitude

288
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
288
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.5K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.5K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

566
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
566
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

3.1K
Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic Surface Copassivation of PbS Colloidal Quantum Dot Films for Efficient Inverted Solar Cells.

ACS applied materials & interfaces·2026
Same author

Correction: Design and chemical composition of a reference phantom for <sup>13</sup>C metabolic MRSI.

Magma (New York, N.Y.)·2026
Same author

Design and chemical composition of a reference phantom for <sup>13</sup>C metabolic MRSI.

Magma (New York, N.Y.)·2026
Same author

Coronary artery segmentation in non-contrast calcium scoring CT images using deep learning.

Computers in biology and medicine·2026
Same author

Advancements in Self-Assembled Molecules to Hybrid Self-Assembled Molecular Interlayers for Optimized Hole Transport Layer in Inverted Perovskite Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Experimental characterisation of porcine subcutaneous adipose tissue under blunt impact up to irreversible deformation.

International journal of legal medicine·2021
Same journal

Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

Scientific reports·2026
Same journal

Microbial contamination of donor corneas and post-keratoplasty endophthalmitis: a comparison between Japanese and U.S. eye banks using cold storage.

Scientific reports·2026
Same journal

Prevalence and contributing factors of virological non-suppression among adult patients on first-line antiretroviral therapy in tertiary hospitals in Ethiopia.

Scientific reports·2026
Same journal

An in vitro comparison of color stability between alkasite and different restorative materials in various staining solutions.

Scientific reports·2026
Same journal

Toward accessible mRNA LNP formulation: systematic evaluation of mixing strategies and key parameters.

Scientific reports·2026
Same journal

A network analysis of personality traits, mentalizing, and psychological health in Chinese college students.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K

Learning hyperparameter predictors for similarity-based multidisciplinary topology optimization.

Mariusz Bujny1, Muhammad Salman Yousaf2, Nathan Zurbrugg3

  • 1Honda Research Institute Europe GmbH, 63073, Offenbach, Germany.

Scientific Reports
|September 8, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a machine learning approach to topology optimization (TO), enabling engineers to control designs by referencing existing structures. This method significantly reduces computational costs for achieving desired material distributions in complex engineering tasks.

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K
Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

6.8K

Related Experiment Videos

Last Updated: Jul 16, 2025

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.1K
Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
07:15

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

6.8K

Area of Science:

  • Engineering
  • Computational Science
  • Materials Science

Background:

  • Topology optimization (TO) is crucial for industrial design, offering optimal material distribution based on design space and loads.
  • Current TO methods struggle with user control over final designs, especially in multidisciplinary tasks with conflicting criteria.
  • Existing similarity-based TO methods require extensive hyperparameter sampling, increasing computational expense.

Purpose of the Study:

  • To develop a novel end-to-end approach for similarity-based topology optimization.
  • To integrate a machine learning model for predicting hyperparameters, reducing computational cost.
  • To provide engineers with greater control over TO designs, ensuring similarity to reference structures.

Main Methods:

  • Proposed a novel end-to-end similarity-based topology optimization (TO) methodology.
  • Integrated a machine learning model to predict hyperparameters for TO methods.
  • Generated training data from an academic linear elastic problem for model generalization.

Main Results:

  • The machine learning model successfully predicts hyperparameters, enabling similarity-based TO at minimal computational cost.
  • The approach demonstrates generalization across linear elastic, nonlinear dynamic crash, and industrial-scale TO problems.
  • Successfully applied to a real-world car hood frame design problem, validating industrial applicability.

Conclusions:

  • The proposed machine learning integrated approach enhances user control in topology optimization.
  • This method significantly reduces the computational burden associated with achieving desired design similarities.
  • The approach is effective for real-world industrial multidisciplinary design problems, such as automotive components.