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LncRNA SNHG1: role in tumorigenesis of multiple human cancers

Huang Zeng1, Shouang Zhou1, Weiqiang Cai1

  • 1School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Cancer Cell International
|September 8, 2023
PubMed

Insights

Small nucleolar RNA host gene 1 (SNHG1) is upregulated in many cancers, playing a key role in tumor development. This review highlights SNHG1

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Small nucleolar RNA host gene 1 (SNHG1) is a critical member of the SNHG family, involved in processing small nucleolar RNAs.
  • Aberrant SNHG1 expression is observed in various human cancers, suggesting its involvement in oncogenesis.

Purpose of the Study:

  • To review the oncogenic roles and molecular mechanisms of SNHG1 in cancer development.
  • To emphasize the clinical significance of SNHG1 in the context of malignant tumors.

Main Methods:

  • Literature review of studies investigating SNHG1 in various cancer types.
  • Analysis of molecular mechanisms underlying SNHG1's function in cancer progression.
  • Compilation of data on the clinical relevance of SNHG1 in cancer diagnosis, prognosis, and treatment.

Main Results:

  • SNHG1 expression is significantly increased in a wide range of cancers.
  • SNHG1 contributes to cancer development through diverse molecular pathways.
  • Clinical studies indicate SNHG1's potential as a diagnostic and prognostic biomarker.

Conclusions:

  • SNHG1 plays a crucial oncogenic role in multiple cancers.
  • SNHG1 holds promise as a potential biomarker for cancer diagnosis, prognosis, and therapeutic strategies.
Keywords:
DiagnosisLncRNAMolecular mechanismPrognosisSNHG1Treatment

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