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Updated: Jul 16, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Factors of Prenatal Depression by Stress-vulnerability and Stress-coping Models
Younglan Kim1, Chae Weon Chung1
1Graduate School, College of Nursing, Seoul National University, Seoul, Korea.
Prenatal depression is influenced by pregnancy stress, self-esteem, life events, and planned pregnancy. Health providers should assess and manage these factors for pregnant women.
Area of Science:
- Psychiatry
- Obstetrics
- Public Health
Background:
- Prenatal depression affects maternal and infant well-being.
- Understanding contributing factors is crucial for effective intervention.
Purpose of the Study:
- Identify factors associated with prenatal depression using stress-vulnerability and stress-coping models.
- Investigate the relationship between depression and psychological/social factors in pregnant women.
Main Methods:
- Cross-sectional survey of 107 pregnant women.
- Utilized Beck Depression Inventory II (BDI II), Self-Esteem, Marital Satisfaction, Pregnancy Stress, Stressful Life Events, and Coping scales.
- Analyzed data using descriptive statistics, t-test, correlation, and stepwise multiple regression.
Main Results:
- 19.6% mild, 15.0% moderate, 0.9% severe prenatal depression (BDI II).
- Prenatal depression correlated positively with pregnancy stress and stressful life events.
- Negative correlations found with self-esteem, marital satisfaction, and coping strategies.
- Pregnancy stress, self-esteem, stressful life events, and planned pregnancy explained 38% of depression variance.
Conclusions:
- Pregnancy stress, low self-esteem, stressful life events, and unplanned pregnancy are significant predictors of prenatal depression.
- Healthcare providers should routinely screen for and address these factors in pregnant populations.
- Interventions targeting these modifiable factors may reduce prenatal depression rates.
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