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Heart Rate Variability as a Surrogate Marker of Severe Chronic Coronary Syndrome in Patients with Obstructive Sleep

Christopher Seifen1, Maria Zisiopoulou2, Katharina Ludwig1

  • 1Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.

Diagnostics (Basel, Switzerland)
|September 9, 2023
PubMed

Insights

Severe chronic coronary syndrome significantly reduces heart rate variability (HRV) in obstructive sleep apnea (OSA) patients. This finding suggests HRV could be a marker for severe CCS in OSA.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Physiology

Background:

  • Obstructive sleep apnea (OSA) is a known risk factor for chronic coronary syndrome (CCS).
  • Both OSA and CCS are independently linked to significant alterations in heart rate variability (HRV).

Purpose of the Study:

  • To investigate if HRV differs between OSA patients with severe CCS and those without known CCS.
  • To explore HRV as a potential indicator of severe CCS in OSA patients.

Main Methods:

  • Retrospective analysis of polysomnography (PSG) data from 32 OSA patients.
  • Comparison of HRV metrics (SDNN and HRVI) between 16 OSA patients with severe CCS and 16 OSA patients without CCS.

Main Results:

  • A statistically significant reduction in both SDNN and HRVI was observed in OSA patients with severe CCS compared to those without CCS (p < 0.05).

Conclusions:

  • Severe CCS significantly impacts short- to long-term HRV in OSA patients.
  • HRV may serve as a surrogate marker for severe CCS in OSA patients, warranting further investigation in larger studies.
Abstract

Keywords:
CCSHRVOSAchronic coronary syndromeheart rate variabilityobstructive sleep apneasurrogate marker

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