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Role of First Trimester Screening Biochemical Markers to Predict Hypertensive Pregnancy Disorders and SGA Neonates-A

Wojciech Górczewski1, Joanna Górecka2, Magdalena Massalska-Wolska3

  • 1Independent Public Health Care Facility "Bl. Marta Wiecka County Hospital", 32-700 Bochnia, Poland.

Healthcare (Basel, Switzerland)
|September 9, 2023
PubMed

Insights

Early pregnancy biochemical markers like PAPP-A and PlGF can predict hypertensive disorders and small-for-gestational-age neonates, improving antenatal surveillance and outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Biochemistry
  • Perinatal Medicine

Background:

  • Early identification of high-risk pregnancies is crucial for improved maternal and neonatal outcomes.
  • Biochemical markers in the first trimester offer potential for predicting adverse pregnancy complications.

Purpose of the Study:

  • To evaluate the predictive value of first-trimester biochemical markers for hypertensive pregnancy disorders (HPD) and small-for-gestational-age (SGA) neonates.
  • To synthesize current literature on biochemical markers associated with adverse pregnancy outcomes.

Main Methods:

  • A systematic literature search was conducted across PubMed, Scopus, and Web of Science.
  • Articles focusing on biochemical markers for HPD and SGA prediction were reviewed.

Main Results:

  • Low levels of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) are associated with increased risk.
  • Elevated soluble fms-like Tyrosine Kinase-1 (sFlt-1), alfa fetoprotein (AFP), and inflammatory markers (β-HGC, INF-γ, TNF-α) are linked to HPD and fetal growth restriction (FGR).
  • PAPP-A and PlGF demonstrated the most significant predictive value for HPD and SGA.

Conclusions:

  • First-trimester biochemical markers are valuable indicators for predicting HPD and SGA.
  • PAPP-A and PlGF are key biomarkers for early risk assessment in pregnancy.
  • Utilizing these markers can enhance antenatal surveillance and potentially improve pregnancy outcomes.

Keywords:
PAPP-APlGFbiochemical markershigh-risk pregnancieshypertensive disorders in pregnancynarrative reviewsmall-for-gestational-age

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