Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sulfur Assimilation01:20

Sulfur Assimilation

38
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reamed and unreamed intramedullary nailing for the treatment of open and closed tibial fractures: a subgroup analysis of randomised trials.

International orthopaedics·2009
Same author

Selective COX-2 inhibitor versus nonselective COX-1 and COX-2 inhibitor in the prevention of heterotopic ossification after total hip arthroplasty: a meta-analysis of randomised trials.

International orthopaedics·2009
Same author

[Study on evaluating sex determining region of the Y as an engrafting track of BMSCs transplantation for repairing osteonecrosis of the femoral head of rabbit].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2009
Same author

Positive association between benign familial infantile convulsions and LGI4.

Brain & development·2009
Same author

Catalytic enantioselective synthesis of chiral phthalides by efficient reductive cyclization of 2-acylarylcarboxylates under aqueous transfer hydrogenation conditions.

Organic letters·2009
Same author

Significance of urinary liver-fatty acid-binding protein in cardiac catheterization in patients with coronary artery disease.

Internal medicine (Tokyo, Japan)·2009

Related Experiment Video

Updated: Jul 16, 2025

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

11.0K

New Insight into the Potential Protective Function of Sulforaphene against ROS-Mediated Oxidative Stress Damage In

Bo Zhang1, Pengtao Liu1, Huakang Sheng1

  • 1State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

International Journal of Molecular Sciences
|September 9, 2023
PubMed
Summary

Sulforaphene (SFE), a natural compound from radish seeds, protects against oxidative stress and kidney damage in mice. It works by reducing harmful molecules and boosting antioxidant defenses, offering potential anti-aging benefits.

Keywords:
Nrf2anti−aginginflammationoxidative damagesulforaphene

More Related Videos

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

4.1K
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.6K

Related Experiment Videos

Last Updated: Jul 16, 2025

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

11.0K
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
09:31

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

4.1K
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.6K

Area of Science:

  • Biochemistry
  • Pharmacology
  • Gerontology

Background:

  • Oxidative stress contributes to free-radical-induced diseases and aging.
  • Isothiocyanates, like Sulforaphene (SFE), are natural compounds with potential health benefits.
  • Understanding the molecular mechanisms of natural compounds is crucial for developing anti-aging strategies.

Purpose of the Study:

  • To investigate the protective effects of Sulforaphene (SFE) against oxidative stress-induced damage.
  • To elucidate the molecular mechanisms underlying SFE's protective actions in vitro and in vivo.
  • To explore SFE's potential as a natural anti-aging compound.

Main Methods:

  • In vitro cell experiments using D-galactose and H2O2 to induce oxidative stress.
  • In vivo mouse models to assess SFE's effects on D-galactose-induced kidney damage.
  • Analysis of reactive oxygen species (ROS), malondialdehyde (MDA), 4-hydroxyalkenals (4-HNE), antioxidant enzyme activity, Nrf2 signaling pathway, and Toll-like receptor 4 (TLR4)-mediated inflammatory response.

Main Results:

  • SFE alleviated D-galactose-induced cytotoxicity and H2O2-induced oxidative damage in cells by inhibiting ROS and apoptosis.
  • In mice, SFE reduced kidney damage by inhibiting ROS, MDA, and 4-HNE production.
  • SFE enhanced antioxidant enzyme activity, upregulated the Nrf2 pathway, and downregulated TLR4-mediated inflammation.

Conclusions:

  • Sulforaphene (SFE) exhibits significant antioxidant and anti-inflammatory properties.
  • SFE protects against oxidative stress-induced damage in both cellular and animal models.
  • SFE's molecular mechanisms involve modulating antioxidant and inflammatory pathways, highlighting its potential for anti-aging applications.